Anti-ADDL antibodies and uses thereof

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of AP-derived diffusible ligands, also known as ADDLs. The antibodies of the 5 invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in metho...

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Bibliographische Detailangaben
Hauptverfasser:	SHUGHRUE, PAUL, BETT, ANDREW J, VIOLA, KIRSTEN L, ZHIQIANG, AN, DODSON, ELIZABETH CHEN, STROHL, WILLIAM R, ROBERT, BREESE, LIANG, XIAOPING, ACTON, PAUL, KINNEY, GENE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to antibodies that differentially recognize multi-dimensional conformations of AP-derived diffusible ligands, also known as ADDLs. The antibodies of the 5 invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods .0 for the preventing and treating diseases associated with soluble oligomers of amyloid @ 1-42.