Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith

Provided herein are Aminopurine Compounds having the following structure: (I) wherein R', R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing Type I diabetes, Type II diabetes, esophagitis, hepatitis, pancreatitis or nephritis, cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos relate condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.