Cytotoxicity mediation of cells evidencing surface expression of CD44

C \NRPortbl\DC0FJB\3492349l .DOC-24/02/2011 CYTOTOXICITY MEDIATION OF CELLS EVIDENCING SURFACE EXPRESSION The use of anti-CD44 monoclonal antibody H460-16-2 for the diagnosis and treatment of cancerous tumors, and binding assays which determine the presence of cells which express a CD44 antigenic mo...

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Hauptverfasser: FINDLAY, HELEN P, HAHN, SUSAN E, YOUNG, DAVID S.F
Format: Patent
Sprache:eng
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Zusammenfassung:C \NRPortbl\DC0FJB\3492349l .DOC-24/02/2011 CYTOTOXICITY MEDIATION OF CELLS EVIDENCING SURFACE EXPRESSION The use of anti-CD44 monoclonal antibody H460-16-2 for the diagnosis and treatment of cancerous tumors, and binding assays which determine the presence of cells which express a CD44 antigenic moiety which specifically binds the monoclonal antibody H460-16-12. The monoclonal antibody is optionally used in combination with one or more 10 chemotherapeutic agents, as a means for initiating the cytotoxic response to tumors.