Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors

Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of -tryptase and are, therefore, useful as pharmaceutical agents. Addit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIANG, GUYAN, NIEDUZAK, THADDEUS R, STOKLOSA, GREGORY T, POLI, GREGORY B, SHUM, PATRICK WAI-KWOK, CHOI-SLEDESKI, YONG MI, ZHAO, ZHICHENG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of -tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).