New histone deacetylase inhibitors based simultaneously on trisubstituted 1H pyrroles and aromatic and heteroaromatic spacers

The present invention refers to compounds derived from trisubstituted 1- pyrrole rings and aromatic rings, which have the following formula (I): wherein: R and R represent, independently, an optionally substituted C-C aryl radical or an optionally substituted heteroaryl radical; A and M represent, independently, a methylene group or a single bond, in which case the adjacent aromatic ring would be attached directly to the amide group; the Y=Z group represents together and indistinctly an oxygen atom, a sulfur atom, a cis-vinylidene group, an imino group, or a methine group with a sp- hybridized carbon atom; X represents indistinctly a methine group, a cis-vinylidene group or a nitrogen atom; and W represents a hydroxyl group, an optionally substituted C-C alkyl group, an optionally substituted heteroaryl group or an optionally substituted C-C aryl group; or a salt, solvate or prodrug thereof, as well as to the process for their preparation and the use thereof for the treatment of cancer.