Anti Notch-1 antibodies

Anti Notch-1 antibodies

This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second ep...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIPPINCOTT, JOHN ANDREW, PENG, QINGHAI, LI, KANG, STONE, DONNA MARIE, HOSTOMSKY, ZDENEK, WEI, PING
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.