Resolution of (plus or minus)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl] carbonyl]amino]phenyl]-1-piperidinyl]acetate

Resolution of (plus or minus)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl] carbonyl]amino]phenyl]-1-piperidinyl]acetate

The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomaltriglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-bipheny...

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Bibliographische Detailangaben
Hauptverfasser: WILLEMSENS, ALBERT LOUIS ANNA, COPMANS, ALEX HERMAN, HOET, JEROME ALBERT JOSEPH, VAN DUN, JOANNES PETRUS, COUCK, WOUTER LOUIS J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to a resolution process of (±)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate to isolate the MTP (microsomaltriglyceride transfer protein) inhibitor methyl (2S)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]-acetate and an epimerisation procedure for racemizing methyl (2R)-phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate.