Sitagliptin synthesis

Sitagliptin synthesis

The present invention relates to novel processes for the preparation of enantiomerically enriched -amino acid derivatives such as -amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHINDE, SURESH, GORE, VINAYAK GOVIND, BHOSLE, PRIYANKA, GADAKAR, MAHESHKUMAR
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to novel processes for the preparation of enantiomerically enriched -amino acid derivatives such as -amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.