Purification process

The present invention comprises a process for detoxification of a bacterial toxin comprising treating the bacterial toxin with a chemical compound that is reactive with primary amine groups wherein over 50% of the toxin retains a molecular weight within 20% of its original molecular weight after tre...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VANDERCAMMEN, ANNE, BIEMANS, RALPH, MERTENS, EMMANUEL, GORAJ, KARINE
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention comprises a process for detoxification of a bacterial toxin comprising treating the bacterial toxin with a chemical compound that is reactive with primary amine groups wherein over 50% of the toxin retains a molecular weight within 20% of its original molecular weight after treatment, as assessed by SDS