Macrocyclic compounds useful as pharmaceuticals
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis,...
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| creator | AKIFUMI KIMURA FABIAN GUSOVSKY TAKATOSHI KAWAI ATSUSHI INOUE HIROSHI SHIROTA ISAO TANAKA MAKOTO KOTAKE NAOKI YONEDA YOSHIHARU MIZUI HIDEKI SUKURAI YOSHIYUKI KAWAKAMI KENZO MURAMOTO SATOSHI YAMAMOTO TOMOHIRO MATSUSHIMA JEANRISTOPHE HARMANGE ROCH BOIVIN JOHN (YUAN) WANG XIANG-YI LI MASAKI GOTO YOSHIHITO EGUCHI YONGUN SHEN YOSHIKAZU KUBOI MEGUMI KAWADA KENICHI CHIBA HONG DU JESSE CHOW MARK SPYVEE CHARLES-ANDRE LEMELIN MASANORI FUJITA YIMIN JIANG |
| description | The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein. |
| format | Patent |
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HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100527&DB=EPODOC&CC=AU&NR=2010201776A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100527&DB=EPODOC&CC=AU&NR=2010201776A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AKIFUMI KIMURA</creatorcontrib><creatorcontrib>FABIAN GUSOVSKY</creatorcontrib><creatorcontrib>TAKATOSHI KAWAI</creatorcontrib><creatorcontrib>ATSUSHI INOUE</creatorcontrib><creatorcontrib>HIROSHI SHIROTA</creatorcontrib><creatorcontrib>ISAO TANAKA</creatorcontrib><creatorcontrib>MAKOTO KOTAKE</creatorcontrib><creatorcontrib>NAOKI YONEDA</creatorcontrib><creatorcontrib>YOSHIHARU MIZUI</creatorcontrib><creatorcontrib>HIDEKI SUKURAI</creatorcontrib><creatorcontrib>YOSHIYUKI KAWAKAMI</creatorcontrib><creatorcontrib>KENZO MURAMOTO</creatorcontrib><creatorcontrib>SATOSHI YAMAMOTO</creatorcontrib><creatorcontrib>TOMOHIRO MATSUSHIMA</creatorcontrib><creatorcontrib>JEANRISTOPHE HARMANGE</creatorcontrib><creatorcontrib>ROCH BOIVIN</creatorcontrib><creatorcontrib>JOHN (YUAN) WANG</creatorcontrib><creatorcontrib>XIANG-YI LI</creatorcontrib><creatorcontrib>MASAKI GOTO</creatorcontrib><creatorcontrib>YOSHIHITO EGUCHI</creatorcontrib><creatorcontrib>YONGUN SHEN</creatorcontrib><creatorcontrib>YOSHIKAZU KUBOI</creatorcontrib><creatorcontrib>MEGUMI KAWADA</creatorcontrib><creatorcontrib>KENICHI CHIBA</creatorcontrib><creatorcontrib>HONG DU</creatorcontrib><creatorcontrib>JESSE CHOW</creatorcontrib><creatorcontrib>MARK SPYVEE</creatorcontrib><creatorcontrib>CHARLES-ANDRE LEMELIN</creatorcontrib><creatorcontrib>MASANORI FUJITA</creatorcontrib><creatorcontrib>YIMIN JIANG</creatorcontrib><title>Macrocyclic compounds useful as pharmaceuticals</title><description>The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZND3TUwuyk-uTM7JTFZIzs8tyC_NSylWKC1OTSvNUUgsVijISCzKTUxOLS3JTE7MKeZhYE0DUqm8UJqbQdnNNcTZQze1ID8-tbgAqDIvtSTeMdTIwNAAiM3NzRwNjYlTBQARcSw5</recordid><startdate>20100527</startdate><enddate>20100527</enddate><creator>AKIFUMI KIMURA</creator><creator>FABIAN GUSOVSKY</creator><creator>TAKATOSHI KAWAI</creator><creator>ATSUSHI INOUE</creator><creator>HIROSHI SHIROTA</creator><creator>ISAO TANAKA</creator><creator>MAKOTO KOTAKE</creator><creator>NAOKI YONEDA</creator><creator>YOSHIHARU MIZUI</creator><creator>HIDEKI SUKURAI</creator><creator>YOSHIYUKI KAWAKAMI</creator><creator>KENZO MURAMOTO</creator><creator>SATOSHI YAMAMOTO</creator><creator>TOMOHIRO MATSUSHIMA</creator><creator>JEANRISTOPHE HARMANGE</creator><creator>ROCH BOIVIN</creator><creator>JOHN (YUAN) WANG</creator><creator>XIANG-YI LI</creator><creator>MASAKI GOTO</creator><creator>YOSHIHITO EGUCHI</creator><creator>YONGUN SHEN</creator><creator>YOSHIKAZU KUBOI</creator><creator>MEGUMI KAWADA</creator><creator>KENICHI CHIBA</creator><creator>HONG DU</creator><creator>JESSE CHOW</creator><creator>MARK SPYVEE</creator><creator>CHARLES-ANDRE LEMELIN</creator><creator>MASANORI FUJITA</creator><creator>YIMIN JIANG</creator><scope>EVB</scope></search><sort><creationdate>20100527</creationdate><title>Macrocyclic compounds useful as pharmaceuticals</title><author>AKIFUMI KIMURA ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Macrocyclic compounds useful as pharmaceuticals |
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