Macrocyclic compounds useful as pharmaceuticals

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	AKIFUMI KIMURA, FABIAN GUSOVSKY, TAKATOSHI KAWAI, ATSUSHI INOUE, HIROSHI SHIROTA, ISAO TANAKA, MAKOTO KOTAKE, NAOKI YONEDA, YOSHIHARU MIZUI, HIDEKI SUKURAI, YOSHIYUKI KAWAKAMI, KENZO MURAMOTO, SATOSHI YAMAMOTO, TOMOHIRO MATSUSHIMA, JEANRISTOPHE HARMANGE, ROCH BOIVIN, JOHN (YUAN) WANG, XIANG-YI LI, MASAKI GOTO, YOSHIHITO EGUCHI, YONGUN SHEN, YOSHIKAZU KUBOI, MEGUMI KAWADA, KENICHI CHIBA, HONG DU, JESSE CHOW, MARK SPYVEE, CHARLES-ANDRE LEMELIN, MASANORI FUJITA, YIMIN JIANG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R 1 -R 11 , t, X, Y, Z and n are as defined herein.