Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

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Bibliographische Detailangaben
Hauptverfasser:	TAO, ZHI-FU, DOHERTY, GEORGE A, SULLIVAN, GERARD M, LESSENE, GUILLAUME LAURENT, PARK, CHANG H, WANG, XILU, ELMORE, STEVEN W, HASVOLD, LISA, MANTEI, ROBERT A, SONG, XIAOHONG, PETROS, ANDREW M, DING, HONG, COLMAN, PETER MALCOLM, MCCLELLAN, WILLIAM J, PARK, CHEOL-MIN, WANG, LE, KUNZER, AARON R, WENDT, MICHAEL D, BRUNCKO, MILAN, DAI, YUJIA, HEXAMER, LAURA, CZABOTAR, PETER EDWARD, SOUERS, ANDREW J, WANG, GARY T
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.