Novel amide derivative and use thereof as medicine

A novel low molecular weight compound which inhibits the production of inducible MMPs, particularly MMP-9, rather than the production of constitutive MMP-2 is provided, and furthermore, a preventive/therapeutic agent for an autoimmune disease or osteoarthritis is provided. An amide derivative repre...

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Bibliographische Detailangaben
Hauptverfasser:	TARAO, AKIKO, ISHIBUCHI, SEIGO, ADACHI, KUNITOMO, HIKAWA, HIDEMASA, ENDOH, JUN-ICHI, TASHIRO, KAORU, MAEDA, KAZUHIRO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A novel low molecular weight compound which inhibits the production of inducible MMPs, particularly MMP-9, rather than the production of constitutive MMP-2 is provided, and furthermore, a preventive/therapeutic agent for an autoimmune disease or osteoarthritis is provided. An amide derivative represented by formula (I) (wherein the respective symbols are as defined in the description), a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof.