Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia

The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties...

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Bibliographische Detailangaben
Hauptverfasser:	WERNER STRUVER, JONATHAN MILLS, PAUL MANSKY, DETLEF ALBRECHT, I-ZU HUANG, MINGJUN LIU, ERIC CONNOR, SHERIN HALFON, DOMINIQUE CHARMOT, RAMAKRISHNAN CHIDAMBARAM, MICHAEL BURDICK, HAN-TING CHANG
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.