Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treat...

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Bibliographische Detailangaben
Hauptverfasser: LU, GENLIANG, PALMER, BRIAN DESMOND, KMENTOVA, IVETA, SONG, MINSOO, WANG, JIANCHENG, CHEN, DIAJUN D, DENNY, WILLIAM ALEXANDER, THOMPSON, ANDREW M, MA, ZHENKUN, COMBRINK, KEITH, SUTHERLAND, HAMISH SCOTT, BLASER, ADRIAN, DING, CHARLES Z
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild- type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as .