Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders

One aspect of the present invention relates to compounds of formula (II), compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DAVID R. ELMALEH, TIMOTHY SHOUP, HONGNING FU
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:One aspect of the present invention relates to compounds of formula (II), compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.