Cross-species-specific bispecific binders

Cross-species-specific bispecific binders

The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well a...

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Bibliographische Detailangaben
Hauptverfasser: SUSANNE STRASSER, CAROLA STEIGER, MIRNAALINI SRISKANDARAJAH, MAJK KVESIC, CLAUDIA BLUMEL, RALF LUTTERBUSE, ELKE BURGHART, PETER KUFER, TOBIAS RAUM, GERT RIETHMULLER, DORIS RAU, MATTHIAS KLINGER, EVELYN EBERT, ROMAN KISCHEL, PETRA MEIER, EVELYNE SCHALLER, PATRICK HOFFMANN, SANDRA WISSING, PETRA MAYER, SUSANNE MANGOLD, RONNY CIERPKA, SUSANNE HAUSMANN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.