Pyrazolopyrimidine analogs and their use as mTOR kinase and PI3 kinase inhibitors

The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrim...

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Bibliographische Detailangaben
Hauptverfasser:	JEROEN VERHEIJEN, KEVIN J. CURRAN, DAVID MALWITZ, SEMIRAMIS AYRAL-KALOUSTIAN, KER YU, ARIE ZASK, MATTHEW GREGORY BURSAVICH, DAVID JAMES RICHARD, MARK LEFEVER, PAWEL WOJCIECH NOWAK, JOSHUA KAPLAN, DEREK CECIL COLE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.