Replicative in vivo gene targeting

REPLICATIVE IN VIVO GENE TARGETING Abstract In some embodiments, the invention provides gene targeting systems that renew or regenerate a gene targeting cassette by various mechanisms of DNA replication to enable s repeated cycles of gene targeting substrate production in vivo. In some embodiments,...

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Hauptverfasser:	ROZWADOWSKI, KEVIN L, LYDIATE, DEREK J
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	REPLICATIVE IN VIVO GENE TARGETING Abstract In some embodiments, the invention provides gene targeting systems that renew or regenerate a gene targeting cassette by various mechanisms of DNA replication to enable s repeated cycles of gene targeting substrate production in vivo. In some embodiments, successive rounds of gene targeting cassette replication may allow the accumulation of multiple molecules of gene targeting substrate per cell or nucleus, so that the presence of more gene targeting substrate may result in a higher frequency of gene targeting events to produce heritable changes in a target host sequence by processes such as nucleic acid 1O recombination and/or repair. 26601^% 1 ilN