Tricyclic amine derivatives as protein tyrosine kinase inhibitors

Tricyclic amine derivatives as protein tyrosine kinase inhibitors

The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.

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Bibliographische Detailangaben
Hauptverfasser: NIJJAR, RAJDEEP KAUR, GILL, ADRIAN LIAM, VICKERSTAFFE, EMMA, TAYLOR, RICHARD DAVID, BESONG, GILBERT EBAI, MURRAY, CHRISTOPHER WILLIAM, CALLAGHAN, OWEN, SAXTY, GORDON, BERDINI, VALERIO, O'BRIEN, MICHAEL ALISTAIR, CONGREVE, MILES STUART, PIKE, ANDREW, CARR, MARIA GRAZIA, GRIFFITHS-JONES, CHARLOTTE MARY, MADIN, ANDREW
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.