Process for the preparation of abacavir

Process for the preparation of abacavir

Process for removal of the amino protective group of a N-acylated {(1S,4R)-4- [2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R = H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process...

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Bibliographische Detailangaben
Hauptverfasser: JULIO CAMPON PARDO, RAMON BERENGUER MAIMO, JORGE MEDRANO RUPEREZ, LAIA ELIAS RIUS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Process for removal of the amino protective group of a N-acylated {(1S,4R)-4- [2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R = H or a (C1-C4)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity.