Structure of the insulin receptor ectodomain

The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the cl...

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Bibliographische Detailangaben
Hauptverfasser:	LAWRENCE, MICHAEL COLIN, LOU, MEIZHEN, ADAMS, TIMOTHY EDWARD, WARD, COLIN WESLEY, GARRETT, THOMAS P. J, SPARROW, LINDSAY GALE, LOVRECZ, GEORGE, MCKERN, NEIL MORETON, STRELSTOV, VICTOR
Format:	Patent
Sprache:	eng
Schlagworte:	CALCULATING CHEMISTRY COMBINATORIAL CHEMISTRY COMPUTING COUNTING ELECTRIC DIGITAL DATA PROCESSING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.