Structure of the insulin receptor ectodomain

The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the cl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MICHAEL COLIN LAWRENCE, TIMOTHY EDWARD ADAMS, GEORGE LOVRECZ, NEIL MORETON MCKERN, THOMAS P. J. GARRETT, COLIN WESLEY WARD, MEIZHEN LOU, VICTOR STRELSTOV, LINDSAY GALE SPARROW
Format:	Patent
Sprache:	eng
Schlagworte:	CALCULATING CHEMISTRY COMBINATORIAL CHEMISTRY COMPUTING COUNTING ELECTRIC DIGITAL DATA PROCESSING INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.