Gene disruptons, compositions and methods relating thereto

The present invention relates to transgenic animals, as wells as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846,...

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Bibliographische Detailangaben
Hauptverfasser:	HEIDI PHILLIPS, TERESA GAIL TOWNSEND, ZHENG-ZHENG SHI, MARY JEAN SPARKS, PETER VOGEL, CHARLES A. MONTGOMERY, JOEL EDWARDS, LESLIE GREEN, TRACY ELLEN WILLIS SEVAUX, JOY ANNE STALA, LING LING CULBERTSON, KATHERIN E. COMBS, ALLISON ANNE BYERS HORNER, KRISTI RAE BOLLINGER, ROSEMARY GIRGIS, DINA REBECCA MCLAIN, JAIME-JO CUNNINGHAM, LAURIE JEANETTE MINZE, FREDERIC DESAUVAGE, BOBBY JOE PAYNE, TRACY TZU-LING TANG
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR TESTING TRAPPING
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Beschreibung
Zusammenfassung:	The present invention relates to transgenic animals, as wells as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PR021184, PRO7434, PRO9822, PRO8933, PRO9836, PRO9854, PRO9863, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration, or correction of diseases or dysfunctions associated with gene disruptions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorder; or developmental abnormalities.