Novel gene disruptions, compositions and methods relating thereto

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, P...

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Bibliographische Detailangaben
Hauptverfasser:	ERIN MARIE MASSEY, HEIDI PHILLIPS, TERESA GAIL TOWNSEND, CAROLINA RANGEL, KATHERIN COMBS, BRYAN IRVING, ELLEN FILVAROFF, ZHENG-ZHENG SHI, PETER VOGEL, MARY JEAN SPARKS, CHARLES A. MONTGOMERY, LIANGFEN FAN, TRACY ELLEN WILLIS-SEVAUX, ALLISON ANNE BYERS-HORNER, JOY STALA, DINA REBECCA MCLAIN, LAURIE JEANETTE MINZE, JAGATH REDDY JUNUTULA, BOBBY JOE PAYNE, FREDERIC DESAUVAGE
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY CARE OF BIRDS, FISHES, INSECTS FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR TRAPPING
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Beschreibung
Zusammenfassung:	The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO218, PRO228, PRO271, PRO273, PRO295, PRO302, PRO305, PRO326, PRO386, PRO655, PRO162, PRO788, PRO792, PRO940, PRO941, PRO1004, PRO1012, PRO1016, PRO474, PRO5238, PRO1069 PRO1111, PRO1113, PRO1130, PRO1195, PRO1271, PRO1865, PRO1879, PRO3446, PRO3543, PRO4329, PRO4352, PRO5733, PRO9859, PRO9864, PRO9904, PRO9907, PRO10013, PRO90948, PRO28694, PRO16089, PRO19563, PRO19675, PRO20084, PRO21434, PRO50332, PRO38465 or PRO346 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.