2,4,5-triphenyl imidazoline derivatives as inhibitors of the interaction between P53 and MDM2 proteins for use as anticancer agents

There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X , X, R , R, R, R, R and R are herein described. The compounds exhibit activity as anticancer agents.

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Bibliographische Detailangaben
Hauptverfasser:	LIU, JIN-JUN, LOVEY, ALLEN JOHN, KONG, NORMAN, PIZZOLATO, GIACOMO, GRAVES, BRADFORD JAMES, WOVKULICH, PETER MICHAEL, SO, SUNG-SAU, ROBERTS, JOHN LAWSON, VU, BINH THANH, DING, QINGJIE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	There is provided a compound of formula (I) and the pharmaceutically acceptable salts and esters thereof wherein X , X, R , R, R, R, R and R are herein described. The compounds exhibit activity as anticancer agents.