Novel macrocyclic inhibitors of hepatitis C virus replication

The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, BIN, LIU, WEIDONG, JIANG, YUTONG, ANDREWS, STEVEN W, MARTIN, PIERRE, SAMMAKIA, TAREK, KENNEDY, APRIL, KAUS, ROBERT, NICHOLS, PAUL, SCHUMACHER, ANDREAS, BARNETT, BRADLEY R, LYON, MICHAEL, EARY, TODD C, SEIWERT, SCOTT D, KERCHER, TIMOTHY, BLATT, LAWRENCE M
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.