Method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide

The invention relates to a method for the production of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide and/or a physiologically-acceptable salt thereof, characterised in that a compound of formula (I), where L = Cl, Br, I, SOF, SOCF, or SOCF is reacted with 3-(4-piperazin-1-yl-buyl)-indol-5-carbonitrile by transition metal catalyzed coupling using Pd complexes and/or the formed 5-(4[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide is converted to an acid addition salt thereof by treatment with an acid and a second method characterised in that a compound of formula (Il) as the base or HX salt (where X= CI, or Br) is reacted with 3-(4-oxo-butyl)-1 H-indol-5-carbonitrile by reductive amination and/or 5-(4-[4-(5-cyano- 3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide is converted to an acid addition salt thereof by treatment with an acid.