Antibodies and Fc fusion proteins with altered immunogenicity

Antibodies and Fc fusion proteins with altered immunogenicity

Variant antibodies and Fc fusion proteins with reduced immunogenicity are described. In particular, the variants of antibodies and Fc fusion proteins have reduced ability to bind one or more human class II MHC molecules are described.

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Bibliographische Detailangaben
Hauptverfasser: SHANNON ALICIA MARSHALL, GREGORY L. MOORE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Variant antibodies and Fc fusion proteins with reduced immunogenicity are described. In particular, the variants of antibodies and Fc fusion proteins have reduced ability to bind one or more human class II MHC molecules are described.