Process for manufacture of simvastatin

Process for manufacture of simvastatin

An improved method for manufacture of simvastatin of formula (I) in high purity. The process for preparation of compound (I) comprises Formula I the steps of agitating a compound of formula (II), Formula II wherein R is hydrogen, NH4+ or an alkali metal in an organic solvent and in an inert atmosphe...

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Hauptverfasser: KADAM, SUBHASH RAJARAM, PATIL, MAHENDRA RAGHUNATH, SASANE, SACHIN ARUN, PATIL, MADHUKAR SHALIGRAM
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator KADAM, SUBHASH RAJARAM
PATIL, MAHENDRA RAGHUNATH
SASANE, SACHIN ARUN
PATIL, MADHUKAR SHALIGRAM
description An improved method for manufacture of simvastatin of formula (I) in high purity. The process for preparation of compound (I) comprises Formula I the steps of agitating a compound of formula (II), Formula II wherein R is hydrogen, NH4+ or an alkali metal in an organic solvent and in an inert atmosphere at a temperature of between 27° C to 40° C in the presence of a weak acid followed by neutralization with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Process for manufacture of simvastatin
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