Process for manufacture of simvastatin

Process for manufacture of simvastatin

An improved method for manufacture of simvastatin of formula (I) in high purity. The process for preparation of compound (I) comprises Formula I the steps of agitating a compound of formula (II), Formula II wherein R is hydrogen, NH4+ or an alkali metal in an organic solvent and in an inert atmosphe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KADAM, SUBHASH RAJARAM, PATIL, MAHENDRA RAGHUNATH, SASANE, SACHIN ARUN, PATIL, MADHUKAR SHALIGRAM
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:An improved method for manufacture of simvastatin of formula (I) in high purity. The process for preparation of compound (I) comprises Formula I the steps of agitating a compound of formula (II), Formula II wherein R is hydrogen, NH4+ or an alkali metal in an organic solvent and in an inert atmosphere at a temperature of between 27° C to 40° C in the presence of a weak acid followed by neutralization with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization.