Aryl nitrogen-containing bicyclic compounds and their use as kinase inhibitors

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingl...

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Bibliographische Detailangaben
Hauptverfasser:	MATTHEW W. MARTIN, WILLIAM H. BUCKNER, ADRIAN LEONARD SMITH, HOLLY L. DEAK, RUSSELL GRACEFFA, PAUL A. TEMPEST, BRIAN K. ALBRECHT, BRADLEY J. HERBERICH, KELVIN SHAM, STEPHANIE D. GEUNS-MEYER, RYAN WHITE, NICK A. PARAS, ERIN F. DIMAURO, MAYA C. THAMAN, JEANRISTOPHE HARMANGE, GREGORY J. HABGOOD, VICTOR J. CEE, JAMES RICHARD FALSEY, DAVID C. MCGOWAN, PHILIP R. OLIVIERI, CRAIG E. MASSE, ANDREW TASKER, BRIAN L. HODOUS, SUSAN ANN TOMLINSON, GUO-QIANG CAO, VINOD F. PATEL, JEAN E. BEMIS, LIPING H. PETTUS, STUART C. CHAFFEE, SHIMIN XU, JOHN L. BUCHANAN, ROBERT M. RZASA, FRENEL F. DEMORIN, GANG LIU, JOSEPH L. KIM, PARTHA P. CHAKRABARTI, DAWEI ZHANG, STEVEN BELLON, ANTHONY REED
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I wherein A1, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.