Peptides and APL-type derivatives of Hsp60 and pharmaceutical compositions

Peptides and APL-type derivatives of Hsp60 and pharmaceutical compositions

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of...

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Hauptverfasser: MARIA DEL CARMEN DOMINGUEZ HORTA, CARELIA COSME DIAZ, JOSE SUAREZ ALBA, NORAILYS LORENZO PEREZ, GABRIEL RAMON PADRON PALOMARES, ARIANA BARBERA BETANCOURT, ARIEL VAZQUEZ BONACHEA, NELSON J. MERINO GARCIA, ARIADNA HERNANDEZ GARCIA, VIVIAN MORERA CORDOVA, NELIA LOPEZ MARIN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.