Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor
This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of...
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| creator | DAVID RICHARD NEWELL STEVEN DAVID REICH ALAN HILARY CALVERT HEIDI MARIE STEINFELDT CHRISTOPHER JONES THEODORE JAMES BORITZKI ZDENEK HOSTOMSKY NICOLA JANE CURTIN RHONDA KAUFMAN ELIZABETH RUTH PLUMMER KAREN J. KLAMERUS IAN J. STRATFORD KAYE JANINE WILLIAMS MOHAMED RAZA DEWJI HUW DAVID THOMAS |
| description | This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer. |
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This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</description><language>eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060330&DB=EPODOC&CC=AU&NR=2005286190A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20060330&DB=EPODOC&CC=AU&NR=2005286190A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DAVID RICHARD NEWELL</creatorcontrib><creatorcontrib>STEVEN DAVID REICH</creatorcontrib><creatorcontrib>ALAN HILARY CALVERT</creatorcontrib><creatorcontrib>HEIDI MARIE STEINFELDT</creatorcontrib><creatorcontrib>CHRISTOPHER JONES</creatorcontrib><creatorcontrib>THEODORE JAMES BORITZKI</creatorcontrib><creatorcontrib>ZDENEK HOSTOMSKY</creatorcontrib><creatorcontrib>NICOLA JANE CURTIN</creatorcontrib><creatorcontrib>RHONDA KAUFMAN</creatorcontrib><creatorcontrib>ELIZABETH RUTH PLUMMER</creatorcontrib><creatorcontrib>KAREN J. 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This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2006</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAKyUgtSixILS3JTFZIzs9NysxLLMnMzysGcQqKMosz89IVCvJzKjUcXQJ0izKT8otTNcECuUB9xanFCpl5GZlJmSX5RTwMrGmJOcWpvFCam0HZzTXE2UM3tSA_PrW4IDE5NS-1JN4x1MjAwNTIwszQ0sDR0Jg4VQBDmDZ5</recordid><startdate>20060330</startdate><enddate>20060330</enddate><creator>DAVID RICHARD NEWELL</creator><creator>STEVEN DAVID REICH</creator><creator>ALAN HILARY CALVERT</creator><creator>HEIDI MARIE STEINFELDT</creator><creator>CHRISTOPHER JONES</creator><creator>THEODORE JAMES BORITZKI</creator><creator>ZDENEK HOSTOMSKY</creator><creator>NICOLA JANE CURTIN</creator><creator>RHONDA KAUFMAN</creator><creator>ELIZABETH RUTH PLUMMER</creator><creator>KAREN J. 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KLAMERUS</creatorcontrib><creatorcontrib>IAN J. STRATFORD</creatorcontrib><creatorcontrib>KAYE JANINE WILLIAMS</creatorcontrib><creatorcontrib>MOHAMED RAZA DEWJI</creatorcontrib><creatorcontrib>HUW DAVID THOMAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DAVID RICHARD NEWELL</au><au>STEVEN DAVID REICH</au><au>ALAN HILARY CALVERT</au><au>HEIDI MARIE STEINFELDT</au><au>CHRISTOPHER JONES</au><au>THEODORE JAMES BORITZKI</au><au>ZDENEK HOSTOMSKY</au><au>NICOLA JANE CURTIN</au><au>RHONDA KAUFMAN</au><au>ELIZABETH RUTH PLUMMER</au><au>KAREN J. KLAMERUS</au><au>IAN J. STRATFORD</au><au>KAYE JANINE WILLIAMS</au><au>MOHAMED RAZA DEWJI</au><au>HUW DAVID THOMAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor</title><date>2006-03-30</date><risdate>2006</risdate><abstract>This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor |
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