Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor

This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of...

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Bibliographische Detailangaben
Hauptverfasser:	DAVID RICHARD NEWELL, STEVEN DAVID REICH, ALAN HILARY CALVERT, HEIDI MARIE STEINFELDT, CHRISTOPHER JONES, THEODORE JAMES BORITZKI, ZDENEK HOSTOMSKY, NICOLA JANE CURTIN, RHONDA KAUFMAN, ELIZABETH RUTH PLUMMER, KAREN J. KLAMERUS, IAN J. STRATFORD, KAYE JANINE WILLIAMS, MOHAMED RAZA DEWJI, HUW DAVID THOMAS
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.