Cyclic amine derivative or salt thereof

Cyclic amine derivative or salt thereof

A compound useful as an NMDA antagonist having a wide safety region which is a therapeutic agent for Alzheimer's disease, vascular dementia (vascular agnosia), Parkinson's disease, ischemic apoplexy, and pains or a preventive agent for these. The compound is an amine derivative or salt the...

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Bibliographische Detailangaben
Hauptverfasser: YAMASAKI, SHINGO, SUZUKI, DAISUKE, KANAYAMA, TAKATOSHI, TOBE, TAKAHIKO, MAENO, KYOICHI, KAWABATA, SHIGEKI, HAYASHIBE, SATOSHI, OHMORI, JUNYA, HOSHII, HIROAKI, SUZUKI, JOTAROU, SHIRAISHI, NOBUYUKI, SHITAKA, YOSHITSUGU
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A compound useful as an NMDA antagonist having a wide safety region which is a therapeutic agent for Alzheimer's disease, vascular dementia (vascular agnosia), Parkinson's disease, ischemic apoplexy, and pains or a preventive agent for these. The compound is an amine derivative or salt thereof characterized by comprising an amine-containing structure (A) and a di- or tricyclic fused ring (indane, tetralone, 4,5,6,7-tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5-b]furan, 2,3-dihydro-1H-cyclopenta[a]naphthalene, etc.) bonded to the structure (A) through X (a bond, lower alkylene, etc.). The NMDA antagonist contains the derivative or salt as an active ingredient.