Convergent synthesis for kahalalide compounds

Convergent synthesis for kahalalide compounds

New synthetic routes to kahalalide compounds are provided. These are based on convergent approaches using orthogonal protecting schemes, where a better control of the intermediates is taken. Kahalalide F or a mimic of kahalalide F is synthesised by coupling a cyclic part with a side chain fragment,...

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Hauptverfasser: LOPEZ MACIA, ANGEL, ALBERICIO PALOMERA, FERNANDO, GRACIA CANTADOR, CAROLINA, FRANCESCH SOLLOSO, ANDRES, GIRALT LLEDO, ERNEST, CUEVAS MARCHANTE, CARMEN, CRUZ RICONDO, LUIS JAVIER, ISIDRO LOBET, ALBERT, ACOSTA CRESPO, GERARDO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:New synthetic routes to kahalalide compounds are provided. These are based on convergent approaches using orthogonal protecting schemes, where a better control of the intermediates is taken. Kahalalide F or a mimic of kahalalide F is synthesised by coupling a cyclic part with a side chain fragment, e.g. according to the reaction (1)