Indene derivatives and process for the preparation thereof

Indene derivatives and process for the preparation thereof

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic sy...

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Hauptverfasser: SUNG-EUN YOO, SUNG DAE PARK, JIN HEE AHN, HYE JUNG KANG, WON HOON JUNG, SUN MEE KIM, HYAE GYEONG CHEON, KOUN HO LEE, NAM GEE KIM, SUNG SOO KIM, JEONG-HYUNG LEE, SEUNG JUN KIM, SEUNG KYU KANG, JAE MOK LEE, SUNG-DON YANG, SANG DAL RHEE, KWANG-ROK KIM, JONG HOON KIM, KIL WOONG MO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.