Heteroaryl piperidine glycine transporter inhibitors

The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunct...

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Bibliographische Detailangaben
Hauptverfasser:	DAVID D. WISNOSKI, WESLEY BLACKABY, ZHIJIAN ZHAO, ELIZABETH NAYLOR, MARK E. DUGGAN, WILLIAM H. LEISTER, ANDREW S. JENNINGS, DAVID HALLETT, SCOTT E. WOLKENBERG, CRAIG W. LINDSLEY, YI WANG, LESLIE J. STREET, GEORGE D. HARTMAN, RICHARD T. LEWIS
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is directed to pyridyl, pyridazinyl, pyrimidinyl and pyrazinyl piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with glycinergic or glutamatergic neurotransmission dysfunction and diseases in which the glycine transporter GlyT1 is involved.