Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same

The present invention provides a compound having a formula: (I) where R is selected from the group consisting of alkyl, -CH(OCH4)OCH, and -(OCH)OCH; n is 0-4; Olig is an oligomer having a formula (I) where L is a optional linker moiety selected from the group consisting of CHO , CHOX , OX , C(O) , C...

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Hauptverfasser: ODENBAUGH, AMY L, EKWURIBE, NNOCHIRI N
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides a compound having a formula: (I) where R is selected from the group consisting of alkyl, -CH(OCH4)OCH, and -(OCH)OCH; n is 0-4; Olig is an oligomer having a formula (I) where L is a optional linker moiety selected from the group consisting of CHO , CHOX , OX , C(O) , C(O)X, NH , NHC(O) , XNHC(O) , NHC(O)X , C(O)NH , C(O)NHX , and (I), where X is alkyl or is not present, Y is N or O or is not present, and R is alkyl; PAG is a linear or branched polyalkylene glycol moiety; R is an alkyl capping moiety if X is present or alkyl if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.