Guanidino-substituted quinazolinone compounds as MC4-R agonists

A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defi...

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Hauptverfasser:	AARON SMITH, RUSTUM S. BOYCE, DAVID L. MUSSO, JASON D. SPEAKE, NATALIA AURRECOECHEA, KIEN S. DU, MICHAEL J. BISHOP, STEPHEN A. THOMSON, KEVIN K. BARVIAN, DANIEL CHU, CHRISTOPHER R. CONLEE, BRIAN D. THOMPSON, BRIAN A. CHAUDER, WILLIAM R. SWAIN, JUDITH DE ARMAS KUNTZ
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein.