New benzamides as PPARY modulators

Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- and C-linked biradical selected from several possibilities; and -Z is a...

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Hauptverfasser:	NATIVIDAD TOLEDO MESA, PEDRO MARRERO GONZALEZ, ANDRES FERNANDEZ GARCIA, CARLES FARRERONS GALLEMI, DIEGO HARO BAUTISTA, CARME SERRA COMAS, ARNAU CORDOMI MONTOYA, JUAN LORENZO CATENA RUIZ, AMADEU LLEBARIA SOLDEVILA, CAROLINA SALCEDO ROCA, IGNACIO JOSE MIQUEL BONO, CARMEN LAGUNAS ARNAL, DOLORS BALSA LOPEZ, ANNA FERDANDEZ SERRAT
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARgamma and PPARgamma/PPARdelta modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.