Protein stabilization in solution

Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin...

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Bibliographische Detailangaben
Hauptverfasser: TROELS KORNFELT, KIRSTEN KRAMER JAKOBSEN, MICHAEL BECH JENSEN, BIRTHE LYKKEGAARD HANSEN
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formulation of a protein. Also provided are new methods of storing proteinaceous compositions. In one aspect, the stored protein is characterized as having an amino-terminal gamma-carboxyglutamic acid (Gla) domain with 9-12 Gla residues.