Substituted carboxylic acids

The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DARREN WHITEHOUSE, MICHAEL C. VAN ZANDT, SHAOJING HU, KERRY COMBS
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.