Cyclic quaternary amino derivatives as modulators of chemokine receptors

Cyclic quaternary amino derivatives as modulators of chemokine receptors

Compounds of formula (1) wherein, m, n, R1, R2, Ra, ALK3, E and Y are as defined in the claims, being potent and selective inhibitors of chemokine binding to the CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, includ...

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Bibliographische Detailangaben
Hauptverfasser: DAVID ALAN OWEN, ROBERT JOHN WATSON, JOHANNES WILHELM GEORG MEISSNER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of formula (1) wherein, m, n, R1, R2, Ra, ALK3, E and Y are as defined in the claims, being potent and selective inhibitors of chemokine binding to the CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.