Diagnostic imaging agents with MMP inhibitory activity

The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory acti...

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Bibliographische Detailangaben
Hauptverfasser:	MICHAEL SCHAFERS, MARIVI MENDIZABAL, DUNCAN WYNN, IAN WILSON, KLAUS KOPKA, BODU LEVKAU, HANS-JORG BREYHOLZ, JOSEPH ARUKWE, ALAN CUTHBERTSON, SALLY-ANN RICKETTS, ANTHONY STOREY, JULIE DAVIS, STEFAN WAGNER, KIRSTY HEYWOOD
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.