Inhibitors of the binding of chemokines I-TAC or SDF-1 to the CCXCKR2 receptor

Inhibitors of the binding of chemokines I-TAC or SDF-1 to the CCXCKR2 receptor

Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Meth...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ANITA MELIKIAN, THOMAS SCHALL, JENNIFER BURNS, JOHN J. WRIGHT, BRIAN E. MCMASTER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.