Synthetic protein as tumor-specific vaccine

The invention provides a GMP compatible method to chemically synthesize proteins which may be advantageously used in compositions for vaccination that are free of biological contaminants. The method uses conventional synthesis of peptides and linking these to yield synthetic proteins that preferably...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SJOERD HENDRIKUS VAN DER BURG, JAN WOUTER DRIJOUT
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides a GMP compatible method to chemically synthesize proteins which may be advantageously used in compositions for vaccination that are free of biological contaminants. The method uses conventional synthesis of peptides and linking these to yield synthetic proteins that preferably comprise all T cell epitopes for an antigen. Preferably an adjuvant is covalently attached to a synthetic protein to yield a fully synthetic vaccine. The invention is illustrated mainly by using HPV protein directed immunity as a model.