A process for the purification of roxithromycin

A process for the purification of roxithromycin with high level of impurity -H comprising subjecting the impure roxithromycin to at least partial dissolution and/or suspension in solvent selected from ethanol, acetonitirle, aromatic solvents and mixture of ethanol and acetonitrile; followed by cryst...

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Bibliographische Detailangaben
Hauptverfasser:	VINOD KUMAR KANSAL, RAKESH R. MISHRA, DHIRENKUMAR N. MISTRY, KAMLESH S. SONI, MAHADEO M. THORAT
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	A process for the purification of roxithromycin with high level of impurity -H comprising subjecting the impure roxithromycin to at least partial dissolution and/or suspension in solvent selected from ethanol, acetonitirle, aromatic solvents and mixture of ethanol and acetonitrile; followed by crystallizing to thereby obtain roxithromycin with desired level of impurity-H of less than 0.5%. The invention also relates to crystalline polymorphic forms B and C of roxithromycin obtained following the above process of purification and having impurity-H of less than 0.5%.