Phenylpyridazine derivatives as ligands for GABA receptors

Phenylpyridazine derivatives as ligands for GABA receptors

A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the alpha2 and/or alpha3 and or alpha5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central ner...

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Bibliographische Detailangaben
Hauptverfasser: PETER BLURTON, RICHARD THOMAS LEWIS, MONIQUE BODIL VAN NEIL, WESLEY PETER BLACKABY, LESLIE JOSEPH STREET, ANDREW JENNINGS, STEVE THOMAS, ANGUS MURRAY MACLEOD, STEPHEN ROBERT FLETCHER, KEVIN WILSON, FRANK BURKAMP
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A class of 4-phenylpyridazine derivatives of Formula (I), being selective ligands for GABAA receptors, in particular having high affinity for the alpha2 and/or alpha3 and or alpha5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.